I've always been interested in the Protheans in the Mass Effect games. They're like the ancient Egyptians of the galaxy.
It's interesting to think about this; It's because of the Protheans that Shepard is able to stop the Reapers (or at least try, what do I know?). Without them, there would be no beacon and so on.
They also creep the living crap out of me. I literally had nightmares after visiting Ilos in the first game.
My Protheans are based on the ones you see in Shepard's vision. I think that in the games, it's still kind of unclear what the species really looked like.
They're sharing one last prayer (whether it's religious or not, I don't know. I don't even know if they have religion) as the Reapers destroy their whole civilization around them. This is symbolized by the vaguely Reaper-shaped blob in the window to the right.
It took me a while to finish this because it kind of creeped me out at the start. However, I'm pretty pleased with how it turned out.
Used Photoshop and a Wacom tablet.